pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can lower panobinostat degrees by ~70% and bring on cure failure.Phenobarbital has been shown to shorten the 50 percent-life of doxycycline for so long as two weeks after barbiturate therapy is discontinue